bug#48978: 28.0.50; native-comp: Error: File error Creating file with prefix

[No Wayman]

Recently upgraded and I'm getting the same error for all of the 
elisp files under /usr/share/emacs/28.0.50/lisp/*
e.g.

Warning (comp): /usr/share/emacs/28.0.50/lisp/progmodes/etags.el: 
Error: File error Creating file with prefix 

Happens regardless of whether Emacs is started with my init or 
with emacs -Q.
As soon as any package along that path is loaded, the errors kick 
in when JIT native compilation is attempted.
Inspecting ~/.emacs.d/eln-cache/28.0.50-d3c1e6c9 confirms the 
error, as none of those package have corresponding .eln files.

Happy to provide more information if necessary 


In GNU Emacs 28.0.50 (build 1, x86_64-pc-linux-gnu, X toolkit, 
cairo version 1.17.4, Xaw3d scroll bars)
of 2021-06-12 built on arch
Repository revision: 0afab352e02d7070a8ced2af53c1d01217400cdf
Repository branch: master
Windowing system distributor 'The X.Org Foundation', version 
11.0.12011000
System Description: Arch Linux

Configured using:
'configure --prefix=/usr --sysconfdir=/etc --libexecdir=/usr/lib
--localstatedir=/var --mandir=/usr/share/man 
--with-gameuser=:games
--with-sound=alsa --with-modules --without-gconf 
--without-gsettings
--enable-link-time-optimization --with-native-compilation
--with-x-toolkit=lucid --with-xft --with-xaw3d
--without-compress-install
'--program-transform-name=s/\([ec]tags\)/\1.emacs/'
'CFLAGS=-march=x86-64 -mtune=generic -O2 -pipe -fno-plt 
-fexceptions
-Wp,-D_FORTIFY_SOURCE=2 -Wformat -Werror=format-security
-fstack-clash-protection -fcf-protection -flto 
-fuse-linker-plugin'
LDFLAGS=-Wl,-O1,--sort-common,--as-needed,-z,relro,-z,now'
Configured features:
ACL CAIRO DBUS FREETYPE GIF GLIB GMP GNUTLS GPM HARFBUZZ JPEG JSON 
LCMS2
LIBOTF LIBSYSTEMD LIBXML2 M17N_FLT MODULES NATIVE_COMP NOTIFY 
INOTIFY
PDUMPER PNG RSVG SECCOMP SOUND THREADS TIFF TOOLKIT_SCROLL_BARS 
X11
XAW3D XDBE XIM XPM LUCID ZLIB
Important settings:
 value of $LANG: en_US.UTF-8
 locale-coding-system: utf-8-unix