Hi Brett,
I don't know if this is absolute best way to do it, but I use the following setup:
Works for me. If this is wrong, somebody let me know!
I have custom settings for staff size and font size (possibly somewhat peculiar for my complex scores.)
Andrew
====
#(set-global-staff-size 12)
\paper
{
#(set-paper-size "a4landscape")
#(define fonts
(set-global-fonts
#:roman "Linux Libertine O"
#:sans "Linux Biolinum O"
#:typewriter "Linux Libertine Mono O"
#:factor (/ staff-height pt 14)
))
}